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Activation of the PI3 kinase pathway can induce skeletal muscle hypertrophy, defined as an increase in skeletal muscle mass. In mammals, skeletal muscle hypertrophy results from an increase in the sizes of preexisting skeletal muscle fibers rather than in the number of fibers. The effects of the PI3 kinase pathway on skeletal muscle have been detected most prominently downstream of IGF-I signaling [2 ]. Recently, mechanical stimuli have been implicated in the regulation of skeletal muscle mass and the maintenance of muscle mass [3. The mechanism of mechanotransduction has been elucidated.


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